Comptes rendus de l’Acade'mie bulgare des Sciences, Vol 71, No1, pp.99-107

Detached Implant Microparticles Induce Periprosthetic Osteolysis

Vesselin Kojouharov, Kolyu Kojouharov, Antonina Gegova, Marian Kanchev


Aseptic loosening of primarily implanted endoprosthesis is considered the most common failure of reconstructive joint surgery. Within the pre-surgical period, 150 destabilised endoprostheses were studied via diagnostic imaging to identify loosened joint components and the degree of periprosthetic osteolysis. The results showed that linear osteolysis accounts for 45.3% of the cases, aggressive osteolysis for 22.1% and stress-shielding for 7.3% of the cases.

The intraoperative examination was aimed to identify the exact location and size of osteolytic defects and to determine the methods for osteoplastic reconstruction. Pathological changes in tissue were studied by means of microbiological, histological and histochemical analysis, whereas tissue fluid underwent microbiological and cytopathological analysis.

Study outcomes provide firm evidence on the causal relationship between detached implant microparticles and tissue dissemination and their key role in the development of periprosthetic osteolysis.

Key words: THA, THR, revision, hip, osteolysis

DOI: 10.7546/CRABS.2018.01.14