Comptes rendus de l’Acade'mie bulgare des Sciences, Vol 57, No10, pp.49-52

INTERACTIONS OF MOLECULAR CHAPERONES HSP40 AND HSP70 WITH HUMAN TRANSCRIPTION FACTOR TBP

R.Jordanova, R.Boteva

ABSTRACT

Human TATA-box binding protein (TBP) is an essential component of the general transcription initiation complex, required for transcription of all nuclear encoded genes. It possesses a polyglutamine (polyQ) stretch of 38 glutamine residues, involved in interactions with other polyQ-containing proteins. This study shows that the molecular chaperone Hsp40 can form transient complexes with TBP. The interactions of TBP with Hsp40 shield the polyQ-fragment and prevent the co-aggregation of TBP with disease polyQ-proteins.

Topic: CHEMISTRY