Effect of Newly Synthesized Methylxanthines on Motility, Fertilization Capacity of Male Gametes and Embryo Quality
Keywords:methylxanthines, spermatozoa, in vitro fertilisation
Male factor infertility affects 30--40% of the subfertile couples worldwide and that poses a significant medical and social issue. Different strategies are developed to increase the fertilization potential of male gametes during procedures of assisted reproduction. One of these approaches is the addition of biologically active molecules, which help to stimulate the motility of spermatozoa. In the current investigation, we analysed the effect of two newly synthesized original methylxanthines (N-61 and T-1) on the kinetic parameters of male gametes and compared it to the action of pentoxifylline (methylxanthine approved for utilization in clinical practice). It has been found that N-61 and T-1 increase the motility and the biological viability of spermatozoa, but do not influence their fertilization capacity and the quality of the obtained embryos.
How to Cite
LicenseCopyright (c) 2023 Proceedings of the Bulgarian Academy of Sciences
Copyright (c) 2022 Proceedings of the Bulgarian Academy of Sciences
Copyright is subject to the protection of the Bulgarian Copyright and Associated Rights Act. The copyright holder of all articles on this site is Proceedings of the Bulgarian Academy of Sciences. If you want to reuse any part of the content, please, contact us.