Vitamin D Status of Pediatric Patients with Type 1 Diabetes Mellitus

Authors

  • Olga Slavcheva-Prodanova University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria
  • Maia Konstantinova University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria
  • Adelina Tsakova Central Clinical Laboratory, Alexandrovska Hospital, Medical University Sofia, Bulgaria
  • Radka Savova University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria
  • Margarita Archinkova University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2022.09.14

Keywords:

pediatrics, type 1 diabetes, vitamin D

Abstract

The aim of this study was to examine the serum levels of 25(OH)vitamin D in pediatric patients with type 1 diabetes and controls, and to determine whether patients had higher prevalence of vitamin D alterations and if they were correlated to disease duration/metabolic control.
A cross-sectional study of 123 patients (65 females) aged 11.84 ± 3.86 years and 46 non-diabetic controls (23 females), aged 10.2 ± 4.69 years was performed. 25(OH)vitamin D level was determined by electrochemiluminescence detection technology.
There was no statistically significant difference between 25(OH)vitamin D levels in diabetic patients and in controls (p = 0.17). The mean level of 25(OH)vitamin D in patients was lower – 71.61 ± 32.34 nmol/L than in controls – 78.32 ± 26.49 nmol/L. We used the Bulgarian Society of Endocrinology recommended ranges to define vitamin D deficiency and insufficiency as 25(OH)vitamin D level < 25 nmol/L and 25–49 nmol/L, respectively. None of the patients and 4.3% of controls (n = 2) had vitamin D deficiency. Vitamin D insufficiency was observed in 19% of patients (n = 23) and in 8.7% of controls (n = 4).
Mean level of HbA1c in all patients was 78 mmol/mol (9.28% ± 1.85) whereas the mean duration of the disease was 5.25 ± 4.03 years. No correlation between metabolic control and disease duration on the one hand, and vitamin D levels on the other, was found.
To our knowledge this is the first study to examine vitamin D levels in Bulgarian pediatric patients with type 1 diabetes. Presence of disease does not influence vitamin D levels – we found no correlation with metabolic control (HbA1c), nor with disease duration. Our results show no significant differences between 25(OH)vitamin D levels in diabetic patients and in controls. Vitamin D insufficiency is slightly but not significantly prevalent in diabetic patients.

Author Biographies

Olga Slavcheva-Prodanova, University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria

Mailing Address:
University Children’s Hospital – Sofia,
Medical University Sofia
11 Akad. Ivan Geshov Blvd
1612 Sofia, Bulgaria

E-mail: o.slavcheva@edu.mu-sofia.bg

Maia Konstantinova, University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria

Mailing Address:
University Children’s Hospital – Sofia,
Medical University Sofia
11 Akad. Ivan Geshov Blvd
1612 Sofia, Bulgaria

E-mail: maiakonstantinova@gmail.com

Adelina Tsakova, Central Clinical Laboratory, Alexandrovska Hospital, Medical University Sofia, Bulgaria

Mailing Address:
Central Clinical Laboratory,
Alexandrovska Hospital,
Medical University Sofia
1 St. Georgi Sofiiski St
1431 Sofia, Bulgaria

E-mail: adelina_d@abv.bg

Radka Savova, University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria

Mailing Address:
University Children’s Hospital – Sofia,
Medical University Sofia
11 Akad. Ivan Geshov Blvd
1612 Sofia, Bulgaria

E-mail: savova_radka@yahoo.com

Margarita Archinkova, University Children’s Hospital – Sofia, Medical University Sofia, Bulgaria

Mailing Address:
University Children’s Hospital – Sofia,
Medical University Sofia
11 Akad. Ivan Geshov Blvd
1612 Sofia, Bulgaria

E-mail: archinkova@yahoo.com

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Published

30-09-2022

How to Cite

[1]
O. Slavcheva-Prodanova, M. Konstantinova, A. Tsakova, R. Savova, and M. Archinkova, “Vitamin D Status of Pediatric Patients with Type 1 Diabetes Mellitus”, C. R. Acad. Bulg. Sci., vol. 75, no. 9, pp. 1356–1363, Sep. 2022.

Issue

Section

Medicine