Analysis of Cell Proliferation and Apoptosis in Virtual Model

Authors

  • Suji Prasad Sudarsanan Nair Jalajakumari Department of Electronics and Instrumentation Engineering, Kongu Engineering College, India
  • Swathi Devaraj Sri Shakthi Institute of Engineering and Technology, India
  • Thangatamilan Manivel Department of Electronics and Instrumentation Engineering, Kongu Engineering College, India
  • Sureshkumar Ramasamy Department of Electronics and Instrumentation Engineering, Kongu Engineering College, India

DOI:

https://doi.org/10.7546/CRABS.2022.10.11

Keywords:

apoptosis, breast cancer, cancer cell death rate, cancer cell repair rate, cell proliferation, chemotherapeutic agent

Abstract

 Breast cancer is the second leading cause of cancer among women globally. Several treatments are involved in breast cancer like surgery, chemotherapy, radiotherapy, and hormone therapy; chemotherapy being used most often. Multicellular systems complications can be deeply understood by analyzing and studying how cells grow, move, divide, die and interact. To examine these factors, we use PhysiCell as our modelling platform. Virtual cell growth analysis is essential to view the cancer cell growth daily. PhysiCell physics-based multicellular simulator is an open-source agent-based simulator used to design a virtual model to analyze the changing cell cycle progression, volume, death, motility, mechanics and processes. Analysis was made on the cancer cell death rate, cell damage rate, and cell repair rate. Data were taken for every 6 hours of simulation and the result confirms that the chemotherapeutic agent kills 45% of cancer cells.

Author Biographies

Suji Prasad Sudarsanan Nair Jalajakumari, Department of Electronics and Instrumentation Engineering, Kongu Engineering College, India

Mailing Address:
Department of Electronics
and Instrumentation Engineering,
Kongu Engineering College
Perundurai, Tamil Nadu, India

E-mail: sjsujiprasad@gmail.com

Swathi Devaraj, Sri Shakthi Institute of Engineering and Technology, India

Mailing Address:
Department of Electrical
and Electronics Engineering,
Sri Shakthi Institute
of Engineering and Technology
Coimbatore, Tamil Nadu, India

E-mail: swathirithik1997@gmail.com

Thangatamilan Manivel, Department of Electronics and Instrumentation Engineering, Kongu Engineering College, India

Mailing Address:
Department of Electronics
and Instrumentation Engineering,
Kongu Engineering College
Perundurai, Tamil Nadu, India

E-mails: thangatamil.m@gmail.com

Sureshkumar Ramasamy, Department of Electronics and Instrumentation Engineering, Kongu Engineering College, India

Mailing Address:
Department of Electronics
and Instrumentation Engineering,
Kongu Engineering College
Perundurai, Tamil Nadu, India

E-mails: sureshkec@gmail.com

Downloads

Published

30-10-2022

How to Cite

[1]
S. Jalajakumari, S. Devaraj, T. Manivel, and S. Ramasamy, “Analysis of Cell Proliferation and Apoptosis in Virtual Model”, C. R. Acad. Bulg. Sci., vol. 75, no. 10, pp. 1483–1490, Oct. 2022.

Issue

Section

Engineering Sciences