Oocyte and Embryo Quality of Infertile Patients with Classic Phenotype Polycystic Ovarian Syndrome after Controlled Ovarian Hyperstimulation

Authors

  • Petya Andreeva Dr. Shterev Hospital and South-West University “Neofit Rilsky”, Bulgaria
  • Luboslava Valkova Dr. Shterev Hospital, Bulgaria
  • Tanya Milachich Dr. Shterev Hospital, Bulgaria and Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences
  • Ivanka Dimova Dr. Shterev Hospital and Department of Medical Genetics, Medical University of Sofia, Bulgaria
  • Atanas Shterev Dr. Shterev Hospital, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2023.02.07

Keywords:

PCOS, ICSI, oocyte quality, embryo quality, pregnancy rate

Abstract

The polycystic ovary syndrome (PCOS) is a combination of conditions, closely associated with female infertility and metabolic syndrome. It is recognized mainly with a polycystic ovary morphology (PCOM) of increased ovarian volume and pearl chain-like follicles on ultrasound, producing a large cohort of growing follicles during controlled ovarian hyperstimulation (COH) that are frequently heterogeneous in size and with poor quantity or quality of mature oocytes. However, recent data has proposed controversial opinions. The objective of the present study was to evaluate the relationship between the classical phenotype PCOS and the oocyte and embryo quality after COH for intracytoplasmic sperm injection (ICSI).

An observational case control study was conducted for a four years period at the IVF department of a private gynecological hospital. Infertile females under 39, who performed COH for ICSI were included. A total of 496 ICSI cycles were divided into two groups – a PCOS group with 109 ICSI cycles and a control group with tube infertility that encompasses 387 ICSI cycles. The main outcome measures were the quantity and quality of the retrieved oocytes and embryos as well as the ICSI outcomes (fertilization rate, implantation rate and clinical pregnancy rate). The statistical analyses were performed, using SPSS version 12.0 and MEDCALC® statistical software and statistical significance was considered at p < 0.05.

Significantly higher mean number of total oocytes (14±6.02 SD vs. 9±3.25 SD; p < 0.0001) and meta-phase II oocytes (10±1.94 SD as opposed to 6±2.89 SD; p = 0.0001), as well as immature and atretic ones were retrieved in the PCOS group compared to the controls (p < 0.0001). However, the fertilization rate did not differ among the two groups (66.8% and 62.4%, respectively). Despite obtaining significantly more embryos in the PCOS patients (9±5.17 SD vs. 6±2.96 SD; p < 0.0001), there were no differences between the two groups regarding the figures of the top quality embryos (25.6% and 29%, respectively), implantation rate (19.7% and 19.95%, respectively) and clinical pregnancy rate (28.4% and 33.6%, respectively, NS).

Patients with classic phenotype PCOS are not associated with poor oocyte and embryo quality or with unfavourable ICSI outcome after controlled ovarian hyperstimulation. 

Author Biographies

Petya Andreeva, Dr. Shterev Hospital and South-West University “Neofit Rilsky”, Bulgaria

Mailing Address:
Dr. Shterev Hospital
25–31 Hristo Blagoev St
Razsadnika
1330 Sofia, Bulgaria

and

South-West University “Neofit Rilsky”
66 Ivan Mihaylov St
2700 Blagoevgrad, Bulgaria

E-mail: andreivp@yahoo.com

Luboslava Valkova, Dr. Shterev Hospital, Bulgaria

Mailing Address:
Dr. Shterev Hospital
25–31 Hristo Blagoev St
Razsadnika
1330 Sofia, Bulgaria

E-mail: petkoval@yahoo.com

Tanya Milachich, Dr. Shterev Hospital, Bulgaria and Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences

Mailing Address:
Dr. Shterev Hospital
25–31 Hristo Blagoev St
Razsadnika
1330 Sofia, Bulgaria

and

Institute of Biology and Immunology
of Reproduction,
Bulgarian Academy of Sciences
73A Tsarigradsko Shosse Blvd
1113 Sofia, Bulgaria

E-mail: tanya_ivf@yahoo.com

Ivanka Dimova, Dr. Shterev Hospital and Department of Medical Genetics, Medical University of Sofia, Bulgaria

Mailing Address:
Dr. Shterev Hospital
25–31 Hristo Blagoev St
Razsadnika
1330 Sofia, Bulgaria

and

Department of Medical Genetics,
Medical University of Sofia
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: ivanka.i.dimova@gmail.com

Atanas Shterev, Dr. Shterev Hospital, Bulgaria

Mailing Address:
Dr. Shterev Hospital
25–31 Hristo Blagoev St
Razsadnika
1330 Sofia, Bulgaria

E-mail: ashterev@gmail.com

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Published

26-02-2023

How to Cite

[1]
P. Andreeva, L. Valkova, T. Milachich, I. Dimova, and A. Shterev, “Oocyte and Embryo Quality of Infertile Patients with Classic Phenotype Polycystic Ovarian Syndrome after Controlled Ovarian Hyperstimulation”, C. R. Acad. Bulg. Sci., vol. 76, no. 2, pp. 229–237, Feb. 2023.

Issue

Section

Biology