Vitamin D Status in Term Newborns and Their Mothers

Authors

  • Stanislava Hitrova-Nikolova Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria
  • Lilia Koleva University General Hospital for Active Care and Emergency Medicine “N. I. Pirogov”, Bulgaria
  • Stefka Georgieva Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria
  • Liliya Vakrilova Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria
  • Valentina Petkova Faculty of Pharmacy, Medical University – Sofia, Bulgaria
  • Milen Dimitrov Faculty of Pharmacy, Medical University – Sofia, Bulgaria
  • Vesela Karamisheva Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2023.04.15

Keywords:

vitamin D, pregnancy, full-term newborn

Abstract

The aim of this study is: 1) To evaluate vitamin D serum levels of fullterm newborns and its association with the maternal levels; 2) To evaluate the diet and the intake of multivitamin supplements of women; 3) To analyze seasonal dependence in serum levels of mother-baby pairs. The prospective study was carried out between July 2018 and February 2020 at the University Hospital of Obstetrics and Gynecology “Maichin dom”, Sofia. The study included 45 full-term newborns and their mothers. Data collected included maternal health, nutrition, vitamin intake, and anthropometric data of the newborns. The laboratory tests performed: maternal serum 25(OH)D levels taken in the third trimester of pregnancy and umbilical cord levels of 25(OH)D. The results show that the mean birth weight was 3234.22 ± 370.29 g and the mean gestational age was 38.13±0.89 weeks. A 25(OH)D sufficiency was found in 58% of mothers and 67% of newborns. A strong positive correlation between maternal and neonatal 25(OH)D concentrations (p = 0.007) was found. A relationship between maternal diet, vitamin supplementation and serum vitamin D levels was observed. The level of 25(OH)D in the umbilical cord in winter is lower than in summer (p = 0.002). Due to the essential role of vitamin D for the normal development of the fetus and the infant, a testing for serum levels of vitamin D during pregnancy is recommended. 

Author Biographies

Stanislava Hitrova-Nikolova, Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria

Mailing Address:
Department of Obstetrics and Gynecology,
Medical University of Sofia
2 Zdrave St
1431 Sofia, Bulgaria

and

Clinic of Neonatology,
University Hospital of Obstetrics
and Gynecology “Maichin dom”
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: stasia_doc@abv.bg

Lilia Koleva, University General Hospital for Active Care and Emergency Medicine “N. I. Pirogov”, Bulgaria

Mailing Address:
University General Hospital for
Active Care and Emergency Medicine
“N. I. Pirogov”
21 Totleben Blvd
1606 Sofia, Bulgaria

E-mail: liliaivanova76@mail.bg

Stefka Georgieva, Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria

Mailing Address:
Department of Obstetrics and Gynecology,
Medical University of Sofia
2 Zdrave St
1431 Sofia, Bulgaria

and

Clinic of Neonatology,
University Hospital of Obstetrics
and Gynecology “Maichin dom”
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: stefi.georgieva@abv.bg

Liliya Vakrilova, Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria

Mailing Address:
Department of Obstetrics and Gynecology,
Medical University of Sofia
2 Zdrave St
1431 Sofia, Bulgaria

and

Clinic of Neonatology,
University Hospital of Obstetrics
and Gynecology “Maichin dom”
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: lilia_vakrilova@mail.bg

Valentina Petkova, Faculty of Pharmacy, Medical University – Sofia, Bulgaria

Mailing Address:
Faculty of Pharmacy,
Medical University – Sofia
2 Dunav St
1000 Sofia, Bulgaria

E-mail: petkovav1972@gmail.com

Milen Dimitrov, Faculty of Pharmacy, Medical University – Sofia, Bulgaria

Mailing Address:
Faculty of Pharmacy,
Medical University – Sofia
2 Dunav St
1000 Sofia, Bulgaria

E-mail: dimitrov.milen@gmail.com

Vesela Karamisheva, Department of Obstetrics and Gynecology, Medical University of Sofia and Clinic of Neonatology, University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria

Mailing Address:
Department of Obstetrics and Gynecology,
Medical University of Sofia
2 Zdrave St
1431 Sofia, Bulgaria

and

Clinic of Neonatology,
University Hospital of Obstetrics
and Gynecology “Maichin dom”
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: vkaramisheva@abv.bg

Downloads

Published

30-04-2023

How to Cite

[1]
S. Hitrova-Nikolova, “Vitamin D Status in Term Newborns and Their Mothers”, C. R. Acad. Bulg. Sci., vol. 76, no. 4, pp. 622–628, Apr. 2023.

Issue

Section

Medicine