Microbial Transformation of Lycorine by Talaromyces pinophilus Isolated from the Rhizosphere of Leucojum aestivum L.

Authors

  • Blaga Mutafova The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
  • Ekaterina Krumova The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
  • Galina Stoyancheva The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
  • Nedelina Kostadinova The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
  • Jeny Miteva-Staleva The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
  • Vladyslava Dishliyska The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
  • Milena Nikolova Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences
  • Maria Angelova The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
  • Strahil Berkov Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences

DOI:

https://doi.org/10.7546/CRABS.2023.05.05

Keywords:

lycorine, Leucojum aestivum L., Talaromyces pinophilus, microbial transformation, 2-oxolycorine

Abstract

In the present study we report on the isolation of 12 strains of filamentous fungi from the rhizosphere of Leucojum aestivum L. (Amaryllidaceae). They were screened for ability to transform the Amaryllidaceae alkaloid lycorine. Gas chromatography-mass spectrometry was applied to analyze the samples. The Talaromyces pinophilus S120 strain was found to transform 19% of lycorine into its 2-oxo-derivative. To the best of our knowledge, this is the first report on transformation of lycorine by a filamentous fungus.

Author Biographies

Blaga Mutafova, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences
Akad. Bonchev St, Bl. 26
1113 Sofia, Bulgaria

E-mail: blaga@microbio.bas.bg

Ekaterina Krumova, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences
Akad. Bonchev St, Bl. 26
1113 Sofia, Bulgaria

E-mail: ekrumova@abv.bg

Galina Stoyancheva, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences
Akad. Bonchev St, Bl. 26
1113 Sofia, Bulgaria

E-mail: galinadinkova@abv.bg

Nedelina Kostadinova, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences
Akad. Bonchev St, Bl. 26
1113 Sofia, Bulgaria

E-mail: nedelinna@abv.bg

Jeny Miteva-Staleva, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences
Akad. Bonchev St, Bl. 26
1113 Sofia, Bulgaria

E-mail: j_m@abv.bg

Vladyslava Dishliyska, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences
Akad. Bonchev St, Bl. 26
1113 Sofia, Bulgaria

E-mail: vladydacheva@yahoo.com

Milena Nikolova, Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences

Mailing Address:
Institute of Biodiversity and Ecosystem Research,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: mtihomirova@gmail.com

Maria Angelova, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences
Akad. Bonchev St, Bl. 26
1113 Sofia, Bulgaria

E-mail: mariange@microbio.bas.bg

Strahil Berkov, Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences

Mailing Address:
Institute of Biodiversity and Ecosystem Research,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: berkov_str@yahoo.com

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Published

29-05-2023

How to Cite

[1]
B. Mutafova, “Microbial Transformation of Lycorine by Talaromyces pinophilus Isolated from the Rhizosphere of Leucojum aestivum L”., C. R. Acad. Bulg. Sci., vol. 76, no. 5, pp. 698–706, May 2023.

Issue

Section

Biology