Antineoplastic Activity of Extracts of the Antarctic Yeast Sporobolomyces roseus AL103 on Urinary Bladder Cancer Cells

Authors

  • Snezhana Rusinova-Videva The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Department of Biotechnology
  • Dilyana Hristova Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Bulgaria
  • Spiro Konstantinov Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2023.05.14

Keywords:

antarctic yeast extracts, bioreactor, in vitro antiproliferative effect, apoptosis

Abstract

Currently, malignant diseases are one of the leading causes of mortality worldwide. Antarctic yeasts represent a poorly explored source of novel bioactive compounds with antineoplastic activity and expected favourable toxicological profile. The aim of the work was the evaluation of the antiproliferative and proapoptotic potential of extracts obtained from the psychrophilic strain Sporobolomyces roseus AL103. Data from MTT dye reduction assay showed that urothelial cancer cell line T-24 was more sensitive (85--101 μg/mL) than the non-tumour cell line (CCL-1- 343 to 432 μg/mL). Apoptosis analysis after treatment with different yeast extracts revealed strong potential to inhibit various antiapoptotic factors as well as selective induction of apoptosis in tumour cells as confirmed by flow cytometry, too.

Author Biographies

Snezhana Rusinova-Videva, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Department of Biotechnology

Mailing Address:
The Stephan Angeloff Institute of Microbiology,
Bulgarian Academy of Sciences,
Department of Biotechnology
139 Ruski Blvd
4000 Plovdiv, Bulgaria

E-mail: jrusinova@abv.bg

Dilyana Hristova, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Bulgaria

Mailing Address:
Department of Pharmacology, Pharmacotherapy and Toxicology,
Faculty of Pharmacy,
Medical University of Sofia
2 Dunav St
1000 Sofia, Bulgaria

E-mail: dil.hristova.m@gmail.com

Spiro Konstantinov, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Bulgaria

Mailing Address:
Department of Pharmacology, Pharmacotherapy and Toxicology,
Faculty of Pharmacy,
Medical University of Sofia
2 Dunav St
1000 Sofia, Bulgaria

E-mail:

konstantinov.spiromihaylov@gmail.com

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Published

29-05-2023

How to Cite

[1]
S. Rusinova-Videva, D. Hristova, and S. Konstantinov, “Antineoplastic Activity of Extracts of the Antarctic Yeast Sporobolomyces roseus AL103 on Urinary Bladder Cancer Cells”, C. R. Acad. Bulg. Sci., vol. 76, no. 5, pp. 778–788, May 2023.

Issue

Section

Medicine