Evaluating the in Vitro Biological Efficacy of Novel Ketoprofen Hybrids against Inflammation, Arthritis, and Oxidative Stress

Authors

  • Stanimir Manolov Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria
  • Dimitar Bojilov Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria
  • Iliyan Ivanov Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2024.06.05

Keywords:

ketoprofen, hybrid molecules, HPSA, IAD, ATA, in vitro, in silico

Abstract

In this study, we disclose the outcomes of the biological assessment of recently synthesized hybrids of ketoprofen with 2-phenylethylamines and 1,2,3,4-tetrahydroisoquinolines. These hybrids were obtained using an environmentally friendly method that minimizes the generation of waste products. The newly acquired hybrids were analysed to evaluate their antioxidant, anti-inflammatory, and anti-arthritic activities. Additionally, as potential drugs exhibiting favourable results, their experimental partition coefficient in a biphasic system of lipids and water (logP) was determined.

Author Biographies

Stanimir Manolov, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

Mailing Address:
Department of Organic Chemistry,
Faculty of Chemistry,
University of Plovdiv “Paisii Hilendarski”
24 Tzar Asen St
4000 Plovdiv, Bulgaria

Email: manolov@uni-plovdiv.bg

Dimitar Bojilov, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

Mailing Address:
Department of Organic Chemistry,
Faculty of Chemistry,
University of Plovdiv “Paisii Hilendarski”
24 Tzar Asen St
4000 Plovdiv, Bulgaria

Email: mbojilov@gmail.com

Iliyan Ivanov, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

Mailing Address:
Department of Organic Chemistry,
Faculty of Chemistry,
University of Plovdiv “Paisii Hilendarski”
24 Tzar Asen St
4000 Plovdiv, Bulgaria

Email: iiiliyan@abv.bg

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Published

30-06-2024

How to Cite

[1]
S. Manolov, D. Bojilov, and I. Ivanov, “Evaluating the in Vitro Biological Efficacy of Novel Ketoprofen Hybrids against Inflammation, Arthritis, and Oxidative Stress”, C. R. Acad. Bulg. Sci., vol. 77, no. 6, pp. 824–830, Jun. 2024.

Issue

Section

Biology